CaCCinh-A01

• Supplier: Tocris Bioscience
• Catalog: 2664
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 407587-33-1
• Chemical Name: 6-(1,1-Dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylicacid
• Formula: C18H21NO4S
• Molecular Weight: 347.43
• Purity: >99 %
• Description: Calcium-activated chloride channel (CaCC) inhibitor (IC 50 ~ 10 μ M). Inhibits CaCC currents in human bronchial and intestinal cells. Also inhibits TMEM16A channels (IC 50 = 2.1 μ M, in TMEM16A-expressing FRT cells).

Product References

Small-molecule screen identifies inhibitors of a human intestinal - Small-molecule screen identifies inhibitors of a human intestinal

De La Fuente R, Namkung W, Mills A, Verkman AS. Mol Pharmacol. 2008 Mar;73(3):758-68. Epub 2007 Dec 14.

TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated - TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated

Namkung W, Phuan PW, Verkman AS. J Biol Chem. 2011 Jan 21;286(3):2365-74.