Calcitriol

• Supplier: Tocris Bioscience
• Catalog: 1159
• Prices: $225.00
• Sizes: 50 µg
• Cas Number: 32222-06-3
• Chemical Name: (1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol
• Formula: C27H44O3
• Molecular Weight: 416.64
• Purity: >99 %
• Description: Active metabolite of vitamin D 3 that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca 2+ absorption and regulates bone Ca 2+ turnover. Exhibits antitumor activity; inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.

Product References

The in vitro effect of calcitriol on parathyroid cell proliferation and - The in vitro effect of calcitriol on parathyroid cell proliferation and

Canalejo A, Almaden Y, Torregrosa V, Gomez-Villamandos JC, Ramos B, Campistol JM, Felsenfeld AJ, Rodriguez M. J Am Soc Nephrol. 2000 Oct;11(10):1865-72.

Calcitriol in cancer treatment: from the lab to the clinic. - Calcitriol in cancer treatment: from the lab to the clinic.

Beer TM, Myrthue A. Mol Cancer Ther. 2004 Mar;3(3):373-81.

TNF receptor superfamily-induced cell death: redox-dependent execution. - TNF receptor superfamily-induced cell death: redox-dependent execution.

Shen HM, Pervaiz S. FASEB J. 2006 Aug;20(10):1589-98.