Calhex 231 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3148
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 652973-93-8
• Chemical Name: 4-Chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-benzamidehydrochloride
• Formula: C25H27ClN2O.HCl
• Molecular Weight: 443.41
• Purity: >98 %
• Description: Negative allosteric modulator of the calcium sensing receptor (CaSR). Blocks increases in [ 3 H]inositol phosphate levels elicited by wild-type hCasR activation (IC 50 = 0.39 μ M in transiently transfected HEK293 cells).

Product References

Modeling and mutagenesis of the binding site of Calhex 231, a novel negative - Modeling and mutagenesis of the binding site of Calhex 231, a novel negative

Petrel C, Kessler A, Maslah F, Dauban P, Dodd RH, Rognan D, Ruat M. J Biol Chem. 2003 Dec 5;278(49):49487-94. Epub 2003 Sep 23.

N1-Benzoyl-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexanes: Development of - N1-Benzoyl-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexanes: Development of

Kessler A, Faure H, Petrel C, Rognan D, Cesario M, Ruat M, Dauban P, Dodd RH. J Med Chem. 2006 Aug 24;49(17):5119-28.

The expression and function of Ca(2+)-sensing receptors in rat mesenteric artery; - The expression and function of Ca(2+)-sensing receptors in rat mesenteric artery;

Weston AH, Absi M, Harno E, Geraghty AR, Ward DT, Ruat M, Dodd RH, Dauban P, Edwards G. Br J Pharmacol. 2008 Jun;154(3):652-62.