Calmidazolium chloride

Name Calmidazolium chloride
Supplier Tocris Bioscience
Catalog 4387
Prices $139.00
Sizes 10 mg
Function Type Antagonist
Cas Number 57265-65-3
Chemical Name 1-[Bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-(2,4-dichlorobenzyloxy)ethyl]-1H-imidazoliumchloride
Formula C31H23Cl7N2O
Molecular Weight 687.7
Purity >98 %
Description Calmodulin antagonist. Inhibits calmodulin-dependent phosphodiesterase and Ca 2+ -transporting ATPase with IC 50 values of 0.15 and 0.35 μ M respectively. Also causes elevation of intracellular calcium in HL-60 cells, independent of calmodulin inhibition.
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Product References

Comparison of the calmodulin antagonists compound 48/80 and calmidazolium. - Comparison of the calmodulin antagonists compound 48/80 and calmidazolium.

Gietzen K. Biochem J. 1983 Dec 15;216(3):611-6.

Effect of calmidazolium analogs on calcium influx in HL-60 cells. - Effect of calmidazolium analogs on calcium influx in HL-60 cells.

Harper JL, Daly JW. Biochem Pharmacol. 2000 Aug 1;60(3):317-24.

Calmidazolium and arachidonate activate a calcium entry pathway that is distinct - Calmidazolium and arachidonate activate a calcium entry pathway that is distinct

Peppiatt CM, Holmes AM, Seo JT, Bootman MD, Collins TJ, McDonald F, Roderick HL. Biochem J. 2004 Aug 1;381(Pt 3):929-39.