Calpeptin

• Supplier: Tocris Bioscience
• Catalog: 2950
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 117591-20-5
• Chemical Name: N-Benzyloxycarbonyl-L-leucylnorleucinal
• Formula: C20H30N2O4
• Molecular Weight: 362.47
• Description: Potent, cell-permeable inhibitor of the Ca 2+ -dependent protease, calpain. Prevents collagen- and thrombin-induced platelet aggregation, probably by blocking calpain induced phospholipase C and thromboxane synthase activation. Potent cathepsin L inhibitor. Recently shown to preferentially inhibit a subset of protein-tyrosine phosphatases.

Product References

Synthesis of a new cell penetrating calpain inhibitor (calpeptin). - Synthesis of a new cell penetrating calpain inhibitor (calpeptin).

Tsujinaka T, Kajiwara Y, Kambayashi J, Sakon M, Higuchi N, Tanaka T, Mori T. Biochem Biophys Res Commun. 1988 Jun 30;153(3):1201-8.

Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins. - Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins.

Sasaki T, Kishi M, Saito M, Tanaka T, Higuchi N, Kominami E, Katunuma N, Murachi T. J Enzyme Inhib. 1990;3(3):195-201.

Cell-penetrating inhibitors of calpain. - Cell-penetrating inhibitors of calpain.

Mehdi S. Trends Biochem Sci. 1991 Apr;16(4):150-3.

Evidence for a calpeptin-sensitive protein-tyrosine phosphatase upstream of the - Evidence for a calpeptin-sensitive protein-tyrosine phosphatase upstream of the

Schoenwaelder SM, Burridge K. J Biol Chem. 1999 May 14;274(20):14359-67.