Calphostin C

• Supplier: Tocris Bioscience
• Catalog: 0448
• Prices: $185.00
• Sizes: 100 µg
• Function Type: Inhibitor
• Cas Number: 121263-19-2
• Chemical Name: (1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethylcarbonicacid4-hydroxyphenylester
• Formula: C44H38O14
• Molecular Weight: 790.76
• Purity: >98 %
• Description: Potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC 50 = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC 50 ~ 40 - 60 nM). Also an antagonist of the Tcf/ β -catenin complex.

Product References

The effect of calphostin C, a potent photodependent protein kinase C inhibitor, - The effect of calphostin C, a potent photodependent protein kinase C inhibitor,

Pollack IF, Kawecki S. J Neurooncol. 1997 Feb;31(3):255-66.

Differential effects of photofrin, 5-aminolevulinic acid and calphostin C on - Differential effects of photofrin, 5-aminolevulinic acid and calphostin C on

Au CM, Luk SK, Jackson CJ, Ng HK, Yow CM, To SS. J Photochem Photobiol B. 2006 Nov 1;85(2):92-101. Epub 2006 Jul 10.

In vitro effects of a small-molecule antagonist of the Tcf/ss-catenin complex on - In vitro effects of a small-molecule antagonist of the Tcf/ss-catenin complex on

Matsuzaki S, Darcha C. PLoS One. 2013 Apr 23;8(4):e61690.