Camptothecin

Name Camptothecin
Supplier Tocris Bioscience
Catalog 3193
Prices $75.00
Sizes 25 mg
Function Type Inhibitor
Cas Number 7689-03-4
Chemical Name (S)-4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Formula C20H16N2O4
Molecular Weight 348.36
Purity >98 %
Description Cytotoxic plant alkaloid with antitumor properties; prototypic DNA topoisomerase I inhibitor. Induces single strand DNA breaks and protein-DNA crosslinks.
Supplier Page Shop

Product References

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. - Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Hsiang YH, Hertzberg R, Hecht S, Liu LF. J Biol Chem. 1985 Nov 25;260(27):14873-8.

DNA topoisomerase poisons as antitumor drugs. - DNA topoisomerase poisons as antitumor drugs.

Liu LF. Annu Rev Biochem. 1989;58:351-75.

Camptothecin derivatives induce regression of human ovarian carcinomas grown in - Camptothecin derivatives induce regression of human ovarian carcinomas grown in

Pantazis P, Kozielski AJ, Mendoza JT, Early JA, Hinz HR, Giovanella BC. Int J Cancer. 1993 Mar 12;53(5):863-71.