Name | Canertinib dihydrochloride |
---|---|
Supplier | Tocris Bioscience |
Catalog | 4792 |
Prices | $119.00, $505.00 |
Sizes | 10 mg, 50 mg |
Function Type | Inhibitor |
Cas Number | 289499-45-2 |
Chemical Name | N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamidedihydrochloride |
Formula | C24H25ClFN5O3.2HCl |
Molecular Weight | 558.86 |
Purity | >98 % |
Description | Potent EGFR kinase inhibitor (IC 50 = 7.4 nM). Blocks autophosphorylation of erb B2. Inhibits growth of A431 tumor xenografts in mice. Cell permeable. |
Supplier Page | Shop |
Petitet F, Jeantaud B, Reibaud M, Imperato A, Dubroeucq MC. Life Sci. 1998;63(1):PL1-6.
Costa B, Giagnoni G, Franke C, Trovato AE, Colleoni M. Br J Pharmacol. 2004 Sep;143(2):247-50. Epub 2004 Aug 16.
Ryberg E, Larsson N, Sjogren S, Hjorth S, Hermansson NO, Leonova J, Elebring T, Nilsson K, Drmota T, Greasley PJ. Br J Pharmacol. 2007 Dec;152(7):1092-101. Epub 2007 Sep 17.
Thomas A, Baillie GL, Phillips AM, Razdan RK, Ross RA, Pertwee RG. Br J Pharmacol. 2007 Mar;150(5):613-23. Epub 2007 Jan 22.