Carboplatin

• Supplier: Tocris Bioscience
• Catalog: 0455
• Prices: $105.00
• Sizes: 50 mg
• Cas Number: 41575-94-4
• Chemical Name: cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)
• Formula: C6H12N2O4Pt
• Molecular Weight: 371.25
• Purity: >99 %
• Description: Antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Enhances radiation-induced single-strand DNA breakage and displays lower nephrotoxicity than analog cisplatin (Cat. No. 2251).

Product References

Increased DNA-binding activity of - Increased DNA-binding activity of

Natarajan G, Malathi R, Holler E. Biochem Pharmacol. 1999 Nov 15;58(10):1625-9.

High accumulation of platinum-DNA adducts in strial marginal cells of the cochlea - High accumulation of platinum-DNA adducts in strial marginal cells of the cochlea

Thomas JP, Lautermann J, Liedert B, Seiler F, Thomale J. Mol Pharmacol. 2006 Jul;70(1):23-9. Epub 2006 Mar 28.