Cariporide

• Supplier: Tocris Bioscience
• Catalog: 4475
• Prices: $99.00, $419.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 159138-80-4
• Chemical Name: N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide
• Formula: C12H17N3O3S
• Molecular Weight: 283.35
• Purity: >99 %
• Description: Selective Na + /H + exchanger isoform 1 (NHE1) inhibitor (IC 50 values are 0.05, 3 and 1000 μ M for NHE1, NHE3 and NHE2 respectively). Attenuates ischemia-induced cardiomyocyte apoptosis in vitro . Reduces cardiac arrhythmia in vivo . Also promotes apoptosis in cancer cells overexpressing NHE1. Orally active.

Product References

Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 - Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1

Scholz W, Albus U, Counillon L, Gogelein H, Lang HJ, Linz W, Weichert A, Scholkens BA. Cardiovasc Res. 1995 Feb;29(2):260-8.

A rapid ischemia-induced apoptosis in isolated rat hearts and its attenuation by - A rapid ischemia-induced apoptosis in isolated rat hearts and its attenuation by

Chakrabarti S, Hoque AN, Karmazyn M. J Mol Cell Cardiol. 1997 Nov;29(11):3169-74.

Cariporide (HOE642), a selective Na+-H+ exchange inhibitor, inhibits the - Cariporide (HOE642), a selective Na+-H+ exchange inhibitor, inhibits the

Teshima Y, Akao M, Jones SP, Marban E. Circulation. 2003 Nov 4;108(18):2275-81. Epub 2003 Oct 20.