Carvedilol

Name Carvedilol
Supplier Tocris Bioscience
Catalog 3337
Prices $95.00
Sizes 50 mg
Function Type Antagonist
Cas Number 72956-09-3
Chemical Name 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol
Formula C24H26N2O4
Molecular Weight 406.47
Purity >99 %
Description Potent β -adrenoceptor and α 1 -adrenoceptor antagonist (K i values are 0.81, 0.96 and 2.2 nM for β 1 -, β 2 - and α 1 -adrenoceptors respectively) that displays antihypertensive and peripheral vasodilatory activity. Blocks cardiac inward-rectifier K + (K IR ) channels, voltage-dependent Ca 2+ channels and exhibits antioxidant properties at higher concentrations.
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Product References

Differential effects of bucindolol and carvedilol on noradenaline-induced - Differential effects of bucindolol and carvedilol on noradenaline-induced

Ponicke K, Heinroth-Hoffmann I, Brodde OE. J Pharmacol Exp Ther. 2002 Apr;301(1):71-6.

Carvedilol blocks cardiac KATP and KG but not IK1 channels by acting at the - Carvedilol blocks cardiac KATP and KG but not IK1 channels by acting at the

Kikuta J, Ishii M, Kishimoto K, Kurachi Y. Eur J Pharmacol. 2006 Jan 4;529(1-3):47-54. Epub 2005 Dec 1.