CASIN

• Supplier: Tocris Bioscience
• Catalog: 2685
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 425399-05-9
• Chemical Name: 2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol
• Formula: C20H22N2O
• Molecular Weight: 306.4
• Purity: >98 %
• Description: Cdc42 GTPase inhibitor (IC 50 = 2 μ M). Reduces active levels of Cdc42 in aged hematopoietic stem cells (HSCs) to that in young HSCs. Reverses the aging-related and polarity phenotype of aged HSCs to that of young HSCs in vivo . Increases histone H4K16 acetylation in aged HSCs.

Product References

Biochemical suppression of small-molecule inhibitors: a strategy to identify - Biochemical suppression of small-molecule inhibitors: a strategy to identify

Peterson JR, Lebensohn AM, Pelish HE, Kirschner MW. Chem Biol. 2006 Apr;13(4):443-52.

Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. - Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation.

Florian MC, Dorr K, Niebel A, Daria D, Schrezenmeier H, Rojewski M, Filippi MD, Hasenberg A, Gunzer M, Scharffetter-Kochanek K, Zheng Y, Geiger H. Cell Stem Cell. 2012 May 4;10(5):520-30.

Chemical approaches to stem cell biology and therapeutics. - Chemical approaches to stem cell biology and therapeutics.

Li W, Li K, Wei W, Ding S. Cell Stem Cell. 2013 Sep 5;13(3):270-83.