CBR 5884

• Supplier: Tocris Bioscience
• Catalog: 3949
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 681159-27-3
• Chemical Name: Ethyl5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylate
• Formula: C14H12N2O4S2
• Molecular Weight: 336.39
• Purity: >98 %
• Description: 3-Phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC 50 = 33 μ M). Decreases de novo serine synthesis in cancer cells. Inhibits proliferation of cancer cell lines having high PHGDH expression levels.

Product References

Nitrogen substitution modifies the activity of cytisine on neuronal nicotinic - Nitrogen substitution modifies the activity of cytisine on neuronal nicotinic

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Long-term exposure to the new nicotinic antagonist 1,2-bisN-cytisinylethane - Long-term exposure to the new nicotinic antagonist 1,2-bisN-cytisinylethane

Riganti L, Matteoni C, Di Angelantonio S, Nistri A, Gaimarri A, Sparatore F, Canu-Boido C, Clementi F, Gotti C. Br J Pharmacol. 2005 Dec;146(8):1096-109.

CC4, a dimer of cytisine, is a selective partial agonist at - CC4, a dimer of cytisine, is a selective partial agonist at

Sala M, Braida D, Pucci L, Manfredi I, Marks MJ, Wageman CR, Grady SR, Loi B, Fucile S, Fasoli F, Zoli M, Tasso B, Sparatore F, Clementi F, Gotti C. Br J Pharmacol. 2013 Feb;168(4):835-49.