CCG 203971

• Supplier: Tocris Bioscience
• Catalog: 5233
• Prices: $99.00, $419.00
• Sizes: 10 mg, 50 mg
• Cas Number: 1443437-74-8
• Chemical Name: N-(4-Chlorophenyl)-1-[3-(2-furanyl)benzoyl]-3-piperidinecarboxamide
• Formula: C23H21ClN2O3
• Molecular Weight: 408.88
• Purity: >98 %
• Description: Antifibrotic agent; inhibits fibrosis by targeting the MRTF/SRF gene transcription pathway. Selectively inhibits proliferation of SSc-derived dermal fibroblasts but not that of normal fibroblasts. Inhibits expression of CTGF, α -SMA, and COL1A2 in SSc fibroblasts as well as in LPA and in TGF β -stimulated fibroblasts. Prevents bleomycin-induced skin thickening and collagen deposition in vivo . Also suppresses PC-3 cell migration in scratch wound assays (IC 50 = 4.2 μ M).

Product References

Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF - Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF

Bell JL, Haak AJ, Wade SM, Kirchhoff PD, Neubig RR, Larsen SD. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3826-32.

Targeting the myofibroblast genetic switch: inhibitors of myocardin-related - Targeting the myofibroblast genetic switch: inhibitors of myocardin-related

Haak AJ, Tsou PS, Amin MA, Ruth JH, Campbell P, Fox DA, Khanna D, Larsen SD, Neubig RR. J Pharmacol Exp Ther. 2014 Jun;349(3):480-6.

Hope for disease-modifying treatment of systemic sclerosis/scleroderma. - Hope for disease-modifying treatment of systemic sclerosis/scleroderma.

Michel MC. J Pharmacol Exp Ther. 2014 Sep;350(3):480-2.