CCG 50014

Name CCG 50014
Supplier Tocris Bioscience
Catalog 2974
Prices $175.00, $709.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 883050-24-6
Chemical Name 4-[(4-Fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione
Formula C16H13FN2O2S
Molecular Weight 316.35
Purity >98 %
Description Potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein (IC 50 values are 30.1 nM and 11.0 μ M for RGS4 and RGS8 respectively). Exhibits >20-fold selectivity for RGS4 over other RGS proteins.
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Product References

A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling - A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling

Blazer LL, Zhang H, Casey EM, Husbands SM, Neubig RR. Biochemistry. 2011 Apr 19;50(15):3181-92.

Small Molecule Inhibitors of Regulator of G Protein Signalling (RGS) Proteins. - Small Molecule Inhibitors of Regulator of G Protein Signalling (RGS) Proteins.

Turner EM, Blazer LL, Neubig RR, Husbands SM. ACS Med Chem Lett. 2012 Feb 9;3(2):146-150.

Conformational dynamics of a regulator of G-protein signaling protein reveals a - Conformational dynamics of a regulator of G-protein signaling protein reveals a

Vashisth H, Storaska AJ, Neubig RR, Brooks CL 3rd. ACS Chem Biol. 2013 Dec 20;8(12):2778-84.