| Name | CCMI |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 1166 |
| Prices | $129.00, $535.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Modulator |
| Cas Number | 917837-54-8 |
| Chemical Name | [N-(4-Chlorophenyl)]-α-[(4-chlorophenyl)-aminomethylene]-3-methyl-5-isoxazoleacetamide |
| Formula | C19H15Cl2N3O2 |
| Molecular Weight | 388.25 |
| Description | Positive allosteric modulator of α 7 neuronal nicotinic acetylcholine receptors (nAChR). Evokes positive modulation of acetylcholine (ACh)-induced EC 5 currents (EC 50 = 0.7 μ M). Exhibits cognitive-enhancing properties in rodent models; displays no cytotoxic effects in PC12 cells or rat primary cortical neurons. |
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Gronlien JH, Hakerud M, Ween H, Thorin-Hagene K, Briggs CA, Gopalakrishnan M, Malysz J. Mol Pharmacol. 2007 Sep;72(3):715-24. Epub 2007 Jun 12.
Hu M, Gopalakrishnan M, Li J. Br J Pharmacol. 2009 Dec;158(8):1857-64.