CCT 018159

Name	CCT 018159
Supplier	Tocris Bioscience
Catalog	1238
Prices	$149.00, $629.00
Sizes	10 mg, 50 mg
Function Type	Inhibitor
Cas Number	171009-07-7
Chemical Name	4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl-1,3-benzenediol
Formula	C20H20N2O4
Molecular Weight	352.39
Purity	>98 %
Description	Novel inhibitor of heat shock protein 90 (Hsp90) ATPase activity (IC 50 = 5.7 μ M) that displays selectivity over human Hsp72 and topoisomerase II. Inhibits proliferation of HCT116 human colon tumor cells and produces upregulation of Hsp70 and downregulation of c-Raf and cdk4. More soluble than 17-AAG (Cat. No. 1515) and is independent of NQO1/DT-diaphorase and P-glycoprotein expression.
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Product References

The identification, synthesis, protein crystal structure and in vitro biochemical - The identification, synthesis, protein crystal structure and in vitro biochemical

Cheung KM, Matthews TP, James K, Rowlands MG, Boxall KJ, Sharp SY, Maloney A, Roe SM, Prodromou C, Pearl LH, Aherne GW, McDonald E, Workman P. Bioorg Med Chem Lett. 2005 Jul 15;15(14):3338-43.

Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 - Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90

Dymock BW, Barril X, Brough PA, Cansfield JE, Massey A, McDonald E, Hubbard RE, Surgenor A, Roughley SD, Webb P, Workman P, Wright L, Drysdale MJ. J Med Chem. 2005 Jun 30;48(13):4212-5.

In vitro biological characterization of a novel, synthetic diaryl pyrazole - In vitro biological characterization of a novel, synthetic diaryl pyrazole

Sharp SY, Boxall K, Rowlands M, Prodromou C, Roe SM, Maloney A, Powers M, Clarke PA, Box G, Sanderson S, Patterson L, Matthews TP, Cheung KM, Ball K, Hayes A, Raynaud F, Marais R, Pearl L, Eccles S, Aherne W, McDonald E, Workman P. Cancer Res. 2007 Mar 1;67(5):2206-16.