CCT 137690

• Supplier: Tocris Bioscience
• Catalog: 4675
• Prices: $245.00, $1,005.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1095382-05-0
• Chemical Name: 6-Bromo-7-[4-[(5-methyl-3-isoxazolyl)methyl]-1-piperazinyl]-2-[4-(4-methyl-1-piperazinyl)phenyl]-3H-imidazo[4,5-b]pyridine
• Formula: C26H31BrN8O
• Molecular Weight: 551.48
• Purity: >98 %
• Description: Potent inhibitor of Aurora kinases (IC 50 values are 0.015, 0.019 and 0.025 μ M at Aurora A, Aurora C and Aurora B respectively). Displays antiproliferative activity in a range of human tumor cell lines. Orally bioavailable.

Product References

Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead - Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead

Bavetsias V, Large JM, Sun C, Bouloc N, Kosmopoulou M, Matteucci M, Wilsher NE, Martins V, Reynisson J, Atrash B, Faisal A, Urban F, Valenti M, de Haven Brandon A, Box G, Raynaud FI, Workman P, Eccles SA, Bayliss R, Blagg J, Linardopoulos S, McDonald E. J Med Chem. 2010 Jul 22;53(14):5213-28.

The aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes - The aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes

Faisal A, Vaughan L, Bavetsias V, Sun C, Atrash B, Avery S, Jamin Y, Robinson SP, Workman P, Blagg J, Raynaud FI, Eccles SA, Chesler L, Linardopoulos S. Mol Cancer Ther. 2011 Nov;10(11):2115-23.