| Name | CCT 241533 dihydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4291 |
| Prices | $279.00 |
| Sizes | 10 mg |
| Function Type | Inhibitor |
| Chemical Name | (3R,4S)-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-3-pyrrolidinemethanoldihydrochloride |
| Formula | C23H27FN4O4.2HCl |
| Molecular Weight | 515.41 |
| Purity | >98 % |
| Description | Potent Chk2 inhibitor (IC 50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide -induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes. |
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