CDDO Im

• Supplier: Tocris Bioscience
• Catalog: 1549
• Prices: $205.00
• Sizes: 10 mg
• Function Type: Activator
• Cas Number: 443104-02-7
• Chemical Name: 1-(2-Cyano-3,12,28-trioxooleana-1,9(11)-dien-28-yl)-1H-imidazole
• Formula: C34H43N3O3
• Molecular Weight: 541.72
• Purity: >98 %
• Description: Nrf2 signaling activator; increases Nrf2 protein expression and enhances Nrf2-dependent cytoprotective gene expression. Inhibits cell growth and induces apoptosis of pancreatic cancer cells in vitro . Also reduces acetaminophen -induced liver injury in mice.

Product References

2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets - 2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets

Samudio I, Konopleva M, Hail N Jr, Shi YX, McQueen T, Hsu T, Evans R, Honda T, Gribble GW, Sporn M, Gilbert HF, Safe S, Andreeff M. J Biol Chem. 2005 Oct 28;280(43):36273-82. Epub 2005 Aug 23.

CDDO-Im protects from acetaminophen hepatotoxicity through induction of - CDDO-Im protects from acetaminophen hepatotoxicity through induction of

Reisman SA, Buckley DB, Tanaka Y, Klaassen CD. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):109-14. doi:

Transcriptional regulation of renal cytoprotective genes by Nrf2 and its - Transcriptional regulation of renal cytoprotective genes by Nrf2 and its

Aleksunes LM, Goedken MJ, Rockwell CE, Thomale J, Manautou JE, Klaassen CD. J Pharmacol Exp Ther. 2010 Oct;335(1):2-12.