c-Di-AMP sodium salt

• Supplier: Tocris Bioscience
• Catalog: 4737
• Prices: $155.00
• Sizes: 702 µg
• Function Type: Agonist
• Chemical Name: 3',5'-Cyclicdiadenylicacidsodiumsalt
• Formula: C20H22N10Na2O12P2
• Molecular Weight: 702.38
• Purity: >98 %
• Description: Endogenous STING and DDX41 agonist; mediates DDX41-STING interaction. Activates STING-dependent IFN- β production in mouse and human cells. Also A 2A inverse agonist. Selectively induces apoptosis of monocytes in human PBMC cultures and in NSG mice transplanted with human CD34 + cells.

Product References

The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, - The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840,

Hughes B, Howat D, Lisle H, Holbrook M, James T, Gozzard N, Blease K, Hughes P, Kingaby R, Warrellow G, Alexander R, Head J, Boyd E, Eaton M, Perry M, Wales M, Smith B, Owens R, Catterall C, Lumb S, Russell A, Allen R, Merriman M, Bloxham D, Higgs G. Br J Pharmacol. 1996 Jul;118(5):1183-91.

CDP840: a novel inhibitor of PDE-4. - CDP840: a novel inhibitor of PDE-4.

Perry MJ, O'Connell J, Walker C, Crabbe T, Baldock D, Russell A, Lumb S, Huang Z, Howat D, Allen R, Merriman M, Walls J, Daniel T, Hughes B, Laliberte F, Higgs GA, Owens RJ. Cell Biochem Biophys. 1998;29(1-2):113-32.

A comparison of the inhibitory activity of PDE4 inhibitors on leukocyte PDE4 - A comparison of the inhibitory activity of PDE4 inhibitors on leukocyte PDE4

Cooper N, Teixeira MM, Warneck J, Miotla JM, Wills RE, Macari DM, Gristwood RW, Hellewell PG. Br J Pharmacol. 1999 Apr;126(8):1863-71.