CDPPB

• Supplier: Tocris Bioscience
• Catalog: 3936
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 781652-57-1
• Chemical Name: 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
• Formula: C23H16N4O
• Molecular Weight: 364.4
• Purity: >98 %
• Description: Brain penetrant, selective positive allosteric modulator at the mGlu 5 receptor (EC 50 values are 10 and 20 nM for human and rat receptors respectively). Antipsychotic; reverses amphetamine-induced locomotor activity and amphetamine-induced deficits in prepulse inhibition in rats.

Product References

Discovery of positive allosteric modulators for the metabotropic glutamate - Discovery of positive allosteric modulators for the metabotropic glutamate

Lindsley CW, Wisnoski DD, Leister WH, O'brien JA, Lemaire W, Williams DL Jr, Burno M, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Duggan ME, Hartman GD, Conn PJ, Huff JR. J Med Chem. 2004 Nov 18;47(24):5825-8.

A novel selective positive allosteric modulator of metabotropic glutamate - A novel selective positive allosteric modulator of metabotropic glutamate

Kinney GG, O'Brien JA, Lemaire W, Burno M, Bickel DJ, Clements MK, Chen TB, Wisnoski DD, Lindsley CW, Tiller PR, Smith S, Jacobson MA, Sur C, Duggan ME, Pettibone DJ, Conn PJ, Williams DL Jr. J Pharmacol Exp Ther. 2005 Apr;313(1):199-206. Epub 2004 Dec 17.

Interaction of novel positive allosteric modulators of metabotropic glutamate - Interaction of novel positive allosteric modulators of metabotropic glutamate

Chen Y, Nong Y, Goudet C, Hemstapat K, de Paulis T, Pin JP, Conn PJ. Mol Pharmacol. 2007 May;71(5):1389-98. Epub 2007 Feb 15.