Celastrol

• Supplier: Tocris Bioscience
• Catalog: 3732
• Prices: $185.00, $755.00
• Sizes: 10 mg, 50 mg
• Function Type: Antioxidant
• Cas Number: 34157-83-0
• Chemical Name: (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oicacid
• Formula: C29H38O4
• Molecular Weight: 450.61
• Purity: >99 %
• Description: Antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF- α -induced NF κ B activation. Also shown to inhibit topoisomerase II activity in vitro (IC 50 = 7.41 μ M).

Product References

Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by - Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by

Nagase M, Oto J, Sugiyama S, Yube K, Takaishi Y, Sakato N. Biosci Biotechnol Biochem. 2003 Sep;67(9):1883-7.

Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses - Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses

Sethi G, Ahn KS, Pandey MK, Aggarwal BB. Blood. 2007 Apr 1;109(7):2727-35.