Celecoxib

• Supplier: Tocris Bioscience
• Catalog: 3203
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 169590-42-5
• Chemical Name: 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide
• Formula: C17H14F3N3O2S
• Molecular Weight: 381.37
• Purity: >99 %
• Description: Selective cyclooxygenase-2 (COX-2) inhibitor (IC 50 values are 15 and 0.04 μ M for COX-1 and COX-2 respectively). Anti-inflammatory with shorter plasma half-life in vivo than SC 58121 (Cat. No. 2895). Displays chemopreventive activity in in vivo tumor models.

Product References

Synthesis and biological evaluation of the 1,5-diarylpyrazole class of - Synthesis and biological evaluation of the 1,5-diarylpyrazole class of

Penning TD, Talley JJ, Bertenshaw SR, Carter JS, Collins PW, Docter S, Graneto MJ, Lee LF, Malecha JW, Miyashiro JM, Rogers RS, Rogier DJ, Yu SS, AndersonGD, Burton EG, Cogburn JN, Gregory SA, Koboldt CM, Perkins WE, Seibert K, Veenhuizen AW, Zhang YY, Isakson PC. J Med Chem. 1997 Apr 25;40(9):1347-65.

Cox-2-selective inhibitors: the new super aspirins. - Cox-2-selective inhibitors: the new super aspirins.

DeWitt DL. Mol Pharmacol. 1999 Apr;55(4):625-31.

Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 - Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2

Harris RE, Alshafie GA, Abou-Issa H, Seibert K. Cancer Res. 2000 Apr 15;60(8):2101-3.