CFM 1571 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3689
• Prices: $199.00
• Sizes: 10 mg
• Function Type: Activator
• Cas Number: 1215548-30-3
• Chemical Name: 3-[3-(Dimethylamino)propoxy]-N-(4-methoxyphenyl)-1-(phenylmethyl)-1H-pyrazole-5-carboxamidehydrochloride
• Formula: C23H28N4O3.HCl
• Molecular Weight: 444.95
• Purity: >99 %
• Description: Soluble guanylyl cyclase (sGC) activator (EC 50 = 5.49 μ M). Does not activate adenylyl cyclase, shows no significant inhibition of phosphodiesterases and displays minimal inhibition of iNOS (25%) and nNOS (17%). Inhibits collagen-stimulated platelet aggregation in vitro (IC 50 = 2.84 μ M).

Product References

Synthesis and biological evaluation of novel pyrazoles and indazoles as - Synthesis and biological evaluation of novel pyrazoles and indazoles as

Selwood DL, Brummell DG, Budworth J, Burtin GE, Campbell RO, Chana SS, Charles IG, Fernandez PA, Glen RC, Goggin MC, Hobbs AJ, Kling MR, Liu Q, Madge DJ, Meillerais S, Powell KL, Reynolds K, Spacey GD, Stables JN, Tatlock MA, Wheeler KA, Wishart G, Woo CK. J Med Chem. 2001 Jan 4;44(1):78-93.

NO-independent stimulators and activators of soluble guanylate cyclase: discovery - NO-independent stimulators and activators of soluble guanylate cyclase: discovery

Evgenov OV, Pacher P, Schmidt PM, Hasko G, Schmidt HH, Stasch JP. Nat Rev Drug Discov. 2006 Sep;5(9):755-68.