CFM 4

• Supplier: Tocris Bioscience
• Catalog: 2586
• Prices: $179.00, $745.00
• Sizes: 10 mg, 50 mg
• Cas Number: 331458-02-7
• Chemical Name: 1-[(2-Chlorophenyl)methyl]-5'-phenyl-spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one
• Formula: C22H16ClN3OS
• Molecular Weight: 405.9
• Purity: >99 %
• Description: CARP-1 mimetic; interferes with CARP-1 binding to APC-2. Enhances CARP-1 expression and induces G 2 /M cell cycle arrest. Induces apoptosis and suppresses cell growth in cancer cells.

Product References

Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis - Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis

Puliyappadamba VT, Wu W, Bevis D, Zhang L, Polin L, Kilkuskie R, Finley RL Jr, Larsen SD, Levi E, Miller FR, Wali A, Rishi AK. J Biol Chem. 2011 Nov 4;286(44):38000-17.

CARP-1 functional mimetics: a novel class of small molecule inhibitors of - CARP-1 functional mimetics: a novel class of small molecule inhibitors of

Ashour AE, Jamal S, Cheryan VT, Muthu M, Zoheir KM, Alafeefy AM, Abd-Allah AR, Levi E, Tarca AL, Polin LA, Rishi AK. PLoS One. 2013 Jun 24;8(6):e66733.