CFTR inh 172

• Supplier: Tocris Bioscience
• Catalog: 1082
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Blocker
• Cas Number: 307510-92-5
• Chemical Name: 4-[[4-Oxo-2-thioxo-3-[3-trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]benzoicacid
• Formula: C18H10F3NO3S2
• Molecular Weight: 409.4
• Purity: >98 %
• Description: Voltage-independent, selective CFTR chloride channel blocker (K i = 300 nM) that alters channel gating. Blocks intestinal fluid secretion induced by cholera toxin and Escherichia coli and suppresses cyst growth in animal models of polycystic kidney disease. Orally active. Inhibits mitochondrial respiration and increases reactive oxygen species (ROS) production independently of CFTR in several cell lines.

Product References

Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks - Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks

Ma T, Thiagarajah JR, Yang H, Sonawane ND, Folli C, Galietta LJ, Verkman AS. J Clin Invest. 2002 Dec;110(11):1651-8.

Altered channel gating mechanism for CFTR inhibition by a high-affinity - Altered channel gating mechanism for CFTR inhibition by a high-affinity

Taddei A, Folli C, Zegarra-Moran O, Fanen P, Verkman AS, Galietta LJ. FEBS Lett. 2004 Jan 30;558(1-3):52-6.

Small-molecule CFTR inhibitors slow cyst growth in polycystic kidney disease. - Small-molecule CFTR inhibitors slow cyst growth in polycystic kidney disease.

Yang B, Sonawane ND, Zhao D, Somlo S, Verkman AS. J Am Soc Nephrol. 2008 Jul;19(7):1300-10.

Rescue of functional F508del cystic fibrosis transmembrane conductance regulator - Rescue of functional F508del cystic fibrosis transmembrane conductance regulator

Rafferty S, Alcolado N, Norez C, Chappe F, Pelzer S, Becq F, Chappe V. J Pharmacol Exp Ther. 2009 Oct;331(1):2-13.