CGP 12177 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3028
• Prices: $75.00, $255.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 64208-32-8
• Chemical Name: 4-[3-[(1,1-Dimethylethyl)amino]2-hydroxypropoxy]-1,3-dihydro-2H-benzimidazol-2-onehydrochloride
• Formula: C14H21N3O3.HCl
• Molecular Weight: 315.8
• Description: Partial agonist at β 3 -adrenoceptors. β 1 - and β 2 -adrenoceptor antagonist (K i values are 0.9, 4 and 88 nM for β 1 , β 2 and β 3 receptors respectively).

Product References

CGP-12177. A hydrophilic beta-adrenergic receptor radioligand reveals high - CGP-12177. A hydrophilic beta-adrenergic receptor radioligand reveals high

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Function and regulation of the beta 3-adrenoceptor. - Function and regulation of the beta 3-adrenoceptor.

Strosberg AD, Pietri-Rouxel F. Trends Pharmacol Sci. 1996 Oct;17(10):373-81.

On the presence of a putative fourth beta-adrenoceptor in human adipose tissue. - On the presence of a putative fourth beta-adrenoceptor in human adipose tissue.

Galitzky J, Langin D, Montastruc JL, Lafontan M, Berlan M. Trends Pharmacol Sci. 1998 May;19(5):164-6.

Metabolic response to various beta-adrenoceptor agonists in beta3-adrenoceptor - Metabolic response to various beta-adrenoceptor agonists in beta3-adrenoceptor

Preitner F, Muzzin P, Revelli JP, Seydoux J, Galitzky J, Berlan M, Lafontan M, Giacobino JP. Br J Pharmacol. 1998 Aug;124(8):1684-8.