CGP 20712 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1514
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 1216905-73-5
• Chemical Name: 1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy]-2-propanoldihydrochloride
• Formula: C23H25F3N4O5.2HCl
• Molecular Weight: 567.39
• Purity: >96 %
• Description: Highly selective and potent β 1 -adrenoceptor antagonist (IC 50 = 0.7 nM). Displays 10,000-fold selectivity over β 2 -adrenoceptors. Also available as part of the β -Adrenoceptor Antagonist Tocriset™ .

Product References

CGP 20712 A: a useful tool for quantitating beta 1- and beta 2-adrenoceptors. - CGP 20712 A: a useful tool for quantitating beta 1- and beta 2-adrenoceptors.

Dooley DJ, Bittiger H, Reymann NC. Eur J Pharmacol. 1986 Oct 14;130(1-2):137-9.

Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology - Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology

Hieble JP, Bondinell WE, Ruffolo RR Jr. J Med Chem. 1995 Sep 1;38(18):3415-44.

Determination of beta-adrenoceptor subtype on rat isolated ventricular myocytes - Determination of beta-adrenoceptor subtype on rat isolated ventricular myocytes

Kitagawa Y, Adachi-Akahane S, Nagao T. Br J Pharmacol. 1995 Sep;116(1):1635-43.