CGP 3466B maleate

Name CGP 3466B maleate
Supplier Tocris Bioscience
Catalog 1024
Prices $129.00, $509.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 200189-97-5
Chemical Name N-(Dibenz[b,f]oxepin-10-ylmethyl)-N-Methyl-N-(2-propynyl)aminemaleate
Formula C19H17NO.C4H4O4
Molecular Weight 391.42
Purity >99 %
Description Orally active glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor. Exhibits antiapoptotic activity via inhibition of GAPDH nuclear translocation and mitochondrial complex 1-dependent H 2 O 2 release. Displays neuroprotective activity in vivo .
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Product References

An orally active anti-apoptotic molecule (CGP 3466B) preserves mitochondria and - An orally active anti-apoptotic molecule (CGP 3466B) preserves mitochondria and

Sagot Y, Toni N, Perrelet D, Lurot S, King B, Rixner H, Mattenberger L, Waldmeier PC, Kato AC. Br J Pharmacol. 2000 Oct;131(4):721-8.

TCH346 prevents motor symptoms and loss of striatal FDOPA uptake in bilaterally - TCH346 prevents motor symptoms and loss of striatal FDOPA uptake in bilaterally

Andringa G, Eshuis S, Perentes E, Maguire RP, Roth D, Ibrahim M, Leenders KL, Cools AR. Neurobiol Dis. 2003 Nov;14(2):205-17.

Clorgyline and other propargylamine derivatives as inhibitors of - Clorgyline and other propargylamine derivatives as inhibitors of

Zoccarato F, Cappellotto M, Alexandre A. J Bioenerg Biomembr. 2008 Aug;40(4):289-96.