CGP 37157

• Supplier: Tocris Bioscience
• Catalog: 3219
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 75450-34-9
• Chemical Name: 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
• Formula: C15H11Cl2NOS
• Molecular Weight: 324.22
• Purity: >99 %
• Description: Selective antagonist of the mitochondrial Na + -Ca 2+ exchanger (IC 50 = 0.4 μ M).

Product References

Selectivity of inhibition of Na(+)-Ca2+ exchange of heart mitochondria by - Selectivity of inhibition of Na(+)-Ca2+ exchange of heart mitochondria by

Cox DA, Conforti L, Sperelakis N, Matlib MA. J Cardiovasc Pharmacol. 1993 Apr;21(4):595-9.

Modulation of intramitochondrial free Ca2+ concentration by antagonists of - Modulation of intramitochondrial free Ca2+ concentration by antagonists of

Cox DA, Matlib MA. Trends Pharmacol Sci. 1993 Nov;14(11):408-13.

CGP37157 modulates mitochondrial Ca2+ homeostasis in cultured rat dorsal root - CGP37157 modulates mitochondrial Ca2+ homeostasis in cultured rat dorsal root

Baron KT, Thayer SA. Eur J Pharmacol. 1997 Dec 11;340(2-3):295-300.

Mitochondria accumulate Ca2+ following intense glutamate stimulation of cultured - Mitochondria accumulate Ca2+ following intense glutamate stimulation of cultured

White RJ, Reynolds IJ. J Physiol. 1997 Jan 1;498 ( Pt 1):31-47.