CGP 52411

• Supplier: Tocris Bioscience
• Catalog: 1247
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 145915-58-8
• Chemical Name: 5,6-Bis(phenylamino)-1H-isoindole-1,3(2H)-dione
• Formula: C20H15N3O2
• Molecular Weight: 329.35
• Purity: >99 %
• Description: Selective inhibitor of the epidermal growth factor receptor (EGFR) (IC 50 = 0.3 μ M in vitro ). Also inhibits and reverses the formation of A β 42 fibers associated with Alzheimer's disease. Eliminates calcium influx potential when coincubated with amyloid β -peptide (1-42) (Cat.No. 1428); reduces neurotoxicity by blocking Ca 2+ influx into neuronal cells.

Product References

4,5-Dianilinophthalimide: a protein-tyrosine kinase inhibitor with selectivity - 4,5-Dianilinophthalimide: a protein-tyrosine kinase inhibitor with selectivity

Buchdunger E, Trinks U, Mett H, Regenass U, Muller M, Meyer T, McGlynn E, Pinna LA, Traxler P, Lydon NB. Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2334-8.

Efficient reversal of Alzheimer's disease fibril formation and elimination of - Efficient reversal of Alzheimer's disease fibril formation and elimination of

Blanchard BJ, Chen A, Rozeboom LM, Stafford KA, Weigele P, Ingram VM. Proc Natl Acad Sci U S A. 2004 Oct 5;101(40):14326-32. Epub 2004 Sep 23.

Direct and selective elimination of specific prions and amyloids by - Direct and selective elimination of specific prions and amyloids by

Wang H, Duennwald ML, Roberts BE, Rozeboom LM, Zhang YL, Steele AD, Krishnan R, Su LJ, Griffin D, Mukhopadhyay S, Hennessy EJ, Weigele P, Blanchard BJ, King J, Deniz AA, Buchwald SL, Ingram VM, Lindquist S, Shorter J. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7159-64. doi: