CGP 57380

• Supplier: Tocris Bioscience
• Catalog: 1248
• Prices: $95.00, $199.00, $825.00
• Sizes: 1 mg, 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 522629-08-9
• Chemical Name: N3-(4-Fluorophenyl)-1H-pyrazolo-[3,4-d]pyrimidine-3,4-diamine
• Formula: C11H9FN6
• Molecular Weight: 244.23
• Purity: >98 %
• Description: Inhibitor of MAP-kinase interacting kinase-1 (Mnk1, MKNK1) (IC 50 = 2.2 μ M) that displays selectivity over p38, JNK1, ERK1, ERK2, PKC and c-src family kinases. Blocks phosphorylation of eIF4E in cellular assays (IC 50 = 3 μ M) and inhibits LPS-induced TNF α expression in macrophages.

Product References

Negative regulation of protein translation by mitogen-activated protein - Negative regulation of protein translation by mitogen-activated protein

Knauf U, Tschopp C, Gram H. Mol Cell Biol. 2001 Aug;21(16):5500-11.

Mnk1 is required for angiotensin II-induced protein synthesis in vascular smooth - Mnk1 is required for angiotensin II-induced protein synthesis in vascular smooth

Ishida M, Ishida T, Nakashima H, Miho N, Miyagawa K, Chayama K, Oshima T, Kambe M, Yoshizumi M. Circ Res. 2003 Dec 12;93(12):1218-24. Epub 2003 Nov 6.

Posttranscriptional regulation of TNFalpha expression via eukaryotic initiation - Posttranscriptional regulation of TNFalpha expression via eukaryotic initiation

Andersson K, Sundler R. Cytokine. 2006 Jan 7;33(1):52-7. Epub 2006 Jan 23.