CGP 60474

• Supplier: Tocris Bioscience
• Catalog: 2731
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 164658-13-3
• Chemical Name: 3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol
• Formula: C18H18ClN5O
• Molecular Weight: 355.82
• Purity: >98 %
• Description: Potent dual cdk1/cdk2 inhibitor (IC 50 values are 20 and 50 nM, respectively). Also displays low micromolar activity at PKC α . Displays reversible G 1 /S cell cycle arrest in U2-OS cells.

Product References

Food intake in free-feeding and energy-deprived lean rats is mediated by the - Food intake in free-feeding and energy-deprived lean rats is mediated by the

Criscione L, Rigollier P, Batzl-Hartmann C, Rueger H, Stricker-Krongrad A, Wyss P, Brunner L, Whitebread S, Yamaguchi Y, Gerald C, Heurich RO, Walker MW, Chiesi M, Schilling W, Hofbauer KG, Levens N. J Clin Invest. 1998 Dec 15;102(12):2136-45.

Potent and selective tools to investigate neuropeptide Y receptors in the central - Potent and selective tools to investigate neuropeptide Y receptors in the central

Dumont Y, Cadieux A, Doods H, Fournier A, Quirion R. Can J Physiol Pharmacol. 2000 Feb;78(2):116-25.

Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the - Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the

Lecklin A, Lundell I, Paananen L, Wikberg JE, Mannisto PT, Larhammar D. Br J Pharmacol. 2002 Apr;135(8):2029-37.