CGP 7930

• Supplier: Tocris Bioscience
• Catalog: 1493
• Prices: $139.00, $579.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 57717-80-3
• Chemical Name: 3,5-bis(1,1-Dimethylethyl)-4-hydroxy-β,β-dimethyl-benzenepropanol
• Formula: C19H32O2
• Molecular Weight: 292.46
• Purity: >98 %
• Description: Positive allosteric modulator of GABA B receptors. Increases the potency and efficacy of GABA at both native and recombinant GABA B receptors (EC 50 values are 5.37 and 4.60 μ M respectively) and enhances the inhibitory effect of the agonist L-baclofen in cultured cortical neurons. Reduces operant self-administration of ethanol in alcohol-preferring rats following i.p. administration.

Product References

Positive allosteric modulation of native and recombinant gamma-aminobutyric - Positive allosteric modulation of native and recombinant gamma-aminobutyric

Urwyler S, Mosbacher J, Lingenhoehl K, Heid J, Hofstetter K, Froestl W, Bettler B, Kaupmann K. Mol Pharmacol. 2001 Nov;60(5):963-71.

Differential modulation by the GABAB receptor allosteric potentiator - Differential modulation by the GABAB receptor allosteric potentiator

Chen Y, Menendez-Roche N, Sher E. J Pharmacol Exp Ther. 2006 Jun;317(3):1170-7. Epub 2006 Feb 28.

The GABA(B) receptor allosteric modulator CGP7930, like baclofen, reduces operant - The GABA(B) receptor allosteric modulator CGP7930, like baclofen, reduces operant

Liang JH, Chen F, Krstew E, Cowen MS, Carroll FY, Crawford D, Beart PM, Lawrence AJ. Neuropharmacology. 2006 Apr;50(5):632-9. Epub 2006 Jan 9.