CGS 20625

• Supplier: Tocris Bioscience
• Catalog: 1241
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 111205-55-1
• Chemical Name: 5,6,7,8,9,10-Hexahydro-2-(4-methoxyphenyl)cyclohepta[b]pyrazolo[3,4-d]pyridin-3(2H)-one
• Formula: C18H19N3O2
• Molecular Weight: 309.36
• Purity: >99 %
• Description: Selective, partial agonist for the benzodiazepine binding site of the GABA A receptor. Potently inhibits [3H]-flunitrazepam binding to central benzodiazepine receptors (IC 50 = 1.3 nM) and displays weak affinity for peripheral benzodiazepine (IC 50 = 0.68 - 2.25 μ M) and GABA binding sites (IC 50 > 10000 μ M). Displays anxiolytic activity in vivo following oral administration. .

Product References

Pharmacology of the pyrazolo-type compounds: agonist, antagonist and inverse - Pharmacology of the pyrazolo-type compounds: agonist, antagonist and inverse

Bennett DA. Physiol Behav. 1987;41(3):241-5.

CGS 20625, a novel pyrazolopyridine anxiolytic. - CGS 20625, a novel pyrazolopyridine anxiolytic.

Williams M, Bennett DA, Loo PS, Braunwalder AF, Amrick CL, Wilson DE, Thompson TN, Schmutz M, Yokoyoma N, Wasley JW. J Pharmacol Exp Ther. 1989 Jan;248(1):89-96.

CGS 20625, a novel pyrazolopyridine with selective anxiolytic activity. - CGS 20625, a novel pyrazolopyridine with selective anxiolytic activity.

Jarvis MF, Bennett DA, Loo PA, Braunwalder AF, Thompson TN, Schmutz M, Yokoyoma N, Wasley JW, Williams M. Prog Clin Biol Res. 1990;361:477-82.