CGS 35066

• Supplier: Tocris Bioscience
• Catalog: 1063
• Prices: $255.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 261619-50-5
• Chemical Name: α-[(S)-(Phosphonomethyl)amino]-3-dibenzofuranpropanoicacid
• Formula: C16H16NO6P
• Molecular Weight: 349.28
• Purity: >99 %
• Description: Potent endothelin-converting enzyme (ECE) inhibitor that displays > 100-fold selectivity over neutral endopeptidase 24.11 (IC 50 values are 22 and 2300 nM respectively). Blocks the hypertensive effects induced by big ET-1 in vitro and reduces the magnitude of cerebral vasospasm following subarachnoid hemorrhage (SAH).

Product References

Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 - Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1

De Lombaert S, Blanchard L, Stamford LB, Tan J, Wallace EM, Satoh Y, Fitt J, Hoyer D, Simonsbergen D, Moliterni J, Marcopoulos N, Savage P, Chou M, Trapani AJ, Jeng AY. J Med Chem. 2000 Feb 10;43(3):488-504.

Pharmacological properties of CGS 35066, a potent and selective - Pharmacological properties of CGS 35066, a potent and selective

Trapani AJ, Beil ME, Bruseo CW, De Lombaert S, Jeng AY. J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S40-3.