CGS 9343B

• Supplier: Tocris Bioscience
• Catalog: 2512
• Prices: $199.00
• Sizes: 10 mg
• Function Type: Antagonist
• Cas Number: 109826-27-9
• Chemical Name: 1,3-Dihydro-1-[1-[(4-methyl-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl)methyl]-4-piperidinyl]-2H-benzimidazol-2-onemaleate
• Formula: C26H28N4O2.C4H4O4
• Molecular Weight: 544.61
• Purity: >98 %
• Description: Calmodulin antagonist; inhibits calmodulin-stimulated cAMP phosphodiesterase activity with an IC 50 of 3.3 nM. Also prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na + , Ca 2+ and K + currents in PC12 cells and inhibits nAChR.

Product References

CGS 9343B, a novel, potent, and selective inhibitor of calmodulin activity. - CGS 9343B, a novel, potent, and selective inhibitor of calmodulin activity.

Norman JA, Ansell J, Stone GA, Wennogle LP, Wasley JW. Mol Pharmacol. 1987 May;31(5):535-40.

Inhibition of membrane currents and rises of intracellular Ca2+ in PC12 cells by - Inhibition of membrane currents and rises of intracellular Ca2+ in PC12 cells by

Neuhaus R, Reber BF. Eur J Pharmacol. 1992 Jun 5;226(2):183-5.

Calmodulin regulates the transcriptional activity of estrogen receptors. - Calmodulin regulates the transcriptional activity of estrogen receptors.

Li L, Li Z, Sacks DB. J Biol Chem. 2003 Jan 10;278(2):1195-200. Epub 2002 Nov 4.