CH 223191

• Supplier: Tocris Bioscience
• Catalog: 2255
• Prices: $155.00, $645.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 301326-22-7
• Chemical Name: 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide
• Formula: C19H19N5O
• Molecular Weight: 333.39
• Purity: >98 %
• Description: Potent aryl hydrocarbon receptor (AhR) antagonist (IC 50 = 30 nM). Exhibits no AhR agonist-like activity (at concentrations up to 100 μ M). Inhibits 2,3,7,8-Tetrachlorodibenzo- p -dioxin (TCDD)-induced AhR-dependent transcription in vitro and reduces TCDD-induced toxicity in vivo . Attenuates Th17 differentiation of naive CD4 T cells and promotes expansion of hematopoietic stem cells in vitro .

Product References

Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid - Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid

Kim SH, Henry EC, Kim DK, Kim YH, Shin KJ, Han MS, Lee TG, Kang JK, Gasiewicz TA, Ryu SH, Suh PG. Mol Pharmacol. 2006 Jun;69(6):1871-8. Epub 2006 Mar 15.

Natural agonists for aryl hydrocarbon receptor in culture medium are essential - Natural agonists for aryl hydrocarbon receptor in culture medium are essential

Veldhoen M, Hirota K, Christensen J, O'Garra A, Stockinger B. J Exp Med. 2009 Jan 16;206(1):43-9.

Aryl hydrocarbon receptor antagonists promote the expansion of human - Aryl hydrocarbon receptor antagonists promote the expansion of human

Boitano AE, Wang J, Romeo R, Bouchez LC, Parker AE, Sutton SE, Walker JR, Flaveny CA, Perdew GH, Denison MS, Schultz PG, Cooke MP. Science. 2010 Sep 10;329(5997):1345-8.

CXCR4 activation maintains a stem cell population in tamoxifen-resistant breast - CXCR4 activation maintains a stem cell population in tamoxifen-resistant breast

Dubrovska A, Hartung A, Bouchez LC, Walker JR, Reddy VA, Cho CY, Schultz PG. Br J Cancer. 2012 Jun 26;107(1):43-52.