CH 275

• Supplier: Tocris Bioscience
• Catalog: 3858
• Prices: $255.00
• Sizes: 1 mg
• Function Type: Agonist
• Cas Number: 174688-78-9
• Formula: C74H96N14O15S2
• Molecular Weight: 1485.8
• Description: Potent somatostatin receptor 1 (sst 1 ) agonist; displays selectivity for sst 1 (IC 50 values are 30.9 nM, 345 nM, > 1 μ M, > 10 μ M and > 10 μ M for human sst 1 , sst 3 , sst 4 , sst 2 and sst 5 respectively). Attenuates somatostatin release in the rat nucleus accumbens.

Product References

Structural basis for the binding specificity of a SSTR1-selective analog of - Structural basis for the binding specificity of a SSTR1-selective analog of

Chen L, Hoeger C, Rivier J, Fitzpatrick VD, Vandlen RL, Tashjian AH Jr. Biochem Biophys Res Commun. 1999 May 19;258(3):689-94.

Potent somatostatin undecapeptide agonists selective for somatostatin receptor 1 - Potent somatostatin undecapeptide agonists selective for somatostatin receptor 1

Rivier JE, Hoeger C, Erchegyi J, Gulyas J, DeBoard R, Craig AG, Koerber SC, Wenger S, Waser B, Schaer JC, Reubi JC. J Med Chem. 2001 Jun 21;44(13):2238-46.

The somatostatin receptor (sst1) modulates the release of somatostatin in the - The somatostatin receptor (sst1) modulates the release of somatostatin in the

Vasilaki A, Papasava D, Hoyer D, Thermos K. Neuropharmacology. 2004 Sep;47(4):612-8.