Ch 55

• Supplier: Tocris Bioscience
• Catalog: 2454
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Cas Number: 110368-33-7
• Chemical Name: 4-[(1E)-3-[3,5-bis(1,1-Dimethylethyl)phenyl]-3-oxo-1-propenyl]benzoicacid
• Formula: C24H28O3
• Molecular Weight: 364.47
• Purity: >98 %
• Description: Highly potent synthetic retinoid that has high affinity for RAR- α and RAR- β receptors and low affinity for cellular retinoic acid binding protein (CRABP). Inhibits rabbit tracheal epithelial cell differentiation by inhibiting transglutaminase and increasing cholesterol sulfate (EC 50 values are 0.02 and 0.03 nM respectively). Induces differentiation of embryonic carcinoma F9 and melanoma S91 cells (EC 50 values are 0.26 and 0.5 nM respectively) and inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC 50 = 1 nM).

Product References

New benzoic acid derivatives with retinoid activity: lack of direct correlation - New benzoic acid derivatives with retinoid activity: lack of direct correlation

Jetten AM, Anderson K, Deas MA, Kagechika H, Lotan R, Rearick JI, Shudo K. Cancer Res. 1987 Jul 1;47(13):3523-7.

Functional studies of newly synthesized benzoic acid derivatives: identification - Functional studies of newly synthesized benzoic acid derivatives: identification

Sato M, Shudo K, Hiragun A. J Cell Physiol. 1988 May;135(2):179-88.