Chaetocin

• Supplier: Tocris Bioscience
• Catalog: 2020
• Prices: $225.00
• Sizes: 1 mg
• Function Type: Inhibitor
• Cas Number: 28097-03-2
• Chemical Name: (3S,3'S,5aR,5aR,10bR,10'bR,11aS,11'aS)-2,2',3,3',5a,5'a,6,6'-octahydro-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-[10b,10'b(11H,11'H)-bi3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4,4'-tetrone
• Formula: C30H28N6O6S4
• Molecular Weight: 696.84
• Purity: >99 %
• Description: Histone methyltransferase SUV39H1 inhibitor (IC 50 = 0.8 μ M). Induces apoptosis in myeloma cell lines in vitro ; exhibits antiproliferative activity in a mouse myeloma model in vivo .

Product References

Identification of a specific inhibitor of the histone methyltransferase - Identification of a specific inhibitor of the histone methyltransferase

Greiner D, Bonaldi T, Eskeland R, Roemer E, Imhof A. Nat Chem Biol. 2005 Aug;1(3):143-5. Epub 2005 Jul 17.

Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity - Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity

Isham CR, Tibodeau JD, Jin W, Xu R, Timm MM, Bible KC. Blood. 2007 Mar 15;109(6):2579-88. Epub 2006 Nov 7.

Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases. - Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases.

Cherblanc FL, Chapman KL, Brown R, Fuchter MJ. Nat Chem Biol. 2013 Mar;9(3):136-7.

Reply to "Chaetocin is a nonspecific inhibitor of histone lysine - Reply to "Chaetocin is a nonspecific inhibitor of histone lysine

Greiner D, Bonaldi T, Eskeland R, Roemer E, Imhof A. Nat Chem Biol. 2013 Mar;9(3):137.