CHC

• Supplier: Tocris Bioscience
• Catalog: 1087
• Prices: $59.00
• Sizes: 50 mg
• Function Type: Inhibitor
• Cas Number: 28166-41-8
• Chemical Name: 2-Cyano-3-(4-hydroxyphenyl)-2-propenoicacid
• Formula: C10H7NO3
• Molecular Weight: 189.17
• Purity: >98 %
• Description: Monocarboxylic acid transport (MCT) inhibitor. Exhibits antitumoral and antiangiogenic activity in gliomas in vivo ; decreases glycolytic metabolism, migration, and invasion in U251 cells. Enhances the effect of antitumor agent temozolomide (Cat No. 2706). Blocks lactate efflux from glioma cells and sensitizes cells to irradiation.

Product References

The low-affinity monocarboxylate transporter MCT4 is adapted to the export of - The low-affinity monocarboxylate transporter MCT4 is adapted to the export of

Dimmer KS, Friedrich B, Lang F, Deitmer JW, Broer S. Biochem J. 2000 Aug 15;350 Pt 1:219-27.

The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic - The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic

Fang J, Quinones QJ, Holman TL, Morowitz MJ, Wang Q, Zhao H, Sivo F, Maris JM, Wahl ML. Mol Pharmacol. 2006 Dec;70(6):2108-15. Epub 2006 Sep 25.

Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as - Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as

Miranda-Goncalves V, Honavar M, Pinheiro C, Martinho O, Pires MM, Pinheiro C, Cordeiro M, Bebiano G, Costa P, Palmeirim I, Reis RM, Baltazar F. Neuro Oncol. 2013 Feb;15(2):172-88.