Chelerythrine chloride

• Supplier: Tocris Bioscience
• Catalog: 5029
• Prices: $139.00
• Sizes: 5 mg
• Function Type: Inhibitor
• Cas Number: 3895-92-9
• Chemical Name: 1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridiniumchloride
• Formula: C21H18ClNO4
• Molecular Weight: 383.83
• Purity: >98 %
• Description: Cell-permeable inhibitor of protein kinase C (IC 50 = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of Bcl XL to Bak (IC 50 = 1.5 μ M) or Bad proteins and stimulates apoptosis.

Product References

Chelerythrine is a potent and specific inhibitor of protein kinase C. - Chelerythrine is a potent and specific inhibitor of protein kinase C.

Herbert JM, Augereau JM, Gleye J, Maffrand JP. Biochem Biophys Res Commun. 1990 Nov 15;172(3):993-9.

Angoline and chelerythrine, benzophenanthridine alkaloids that do not inhibit - Angoline and chelerythrine, benzophenanthridine alkaloids that do not inhibit

Lee SK, Qing WG, Mar W, Luyengi L, Mehta RG, Kawanishi K, Fong HH, Beecher CW, Kinghorn AD, Pezzuto JM. J Biol Chem. 1998 Jul 31;273(31):19829-33.

Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis - Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis

Yu R, Mandlekar S, Tan TH, Kong AN. J Biol Chem. 2000 Mar 31;275(13):9612-9.

Identification of chelerythrine as an inhibitor of BclXL function. - Identification of chelerythrine as an inhibitor of BclXL function.

Chan SL, Lee MC, Tan KO, Yang LK, Lee AS, Flotow H, Fu NY, Butler MS, Soejarto DD, Buss AD, Yu VC. J Biol Chem. 2003 Jun 6;278(23):20453-6. Epub 2003 Apr 17.