Chetomin

• Supplier: Tocris Bioscience
• Catalog: 1330
• Prices: $189.00
• Sizes: 1 mg
• Cas Number: 1403-36-7
• Chemical Name: (3S,5aR,10bS,11aS)-2,3,5a,6,10b,11-hexahydro-3-(hydroxymethyl)-10b-(3-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl)methyl]-1H-indol-1-yl]-2-methyl-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione
• Formula: C31H30N6O6S4
• Molecular Weight: 710.87
• Purity: >98 %
• Description: Targets the CH1 domain of CBP/p300; inhibits interaction of HIF-1 α , HIF-2 α and STAT2 with CBP/p300. Attenuates hypoxia-induced gene expression in vitro and in vivo ; radiosensitizes human HT 1080 fibrosarcoma cells in vitro .

Product References

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible - Small molecule blockade of transcriptional coactivation of the hypoxia-inducible

Kung AL, Zabludoff SD, France DS, Freedman SJ, Tanner EA, Vieira A, Cornell-Kennon S, Lee J, Wang B, Wang J, Memmert K, Naegeli HU, Petersen F, Eck MJ, Bair KW, Wood AW, Livingston DM. Cancer Cell. 2004 Jul;6(1):33-43.

Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and - Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and

Staab A, Loeffler J, Said HM, Diehlmann D, Katzer A, Beyer M, Fleischer M, Schwab F, Baier K, Einsele H, Flentje M, Vordermark D. BMC Cancer. 2007 Nov 13;7:213.

Transcriptional switches: chemical approaches to gene regulation. - Transcriptional switches: chemical approaches to gene regulation.

Lee LW, Mapp AK. J Biol Chem. 2010 Apr 9;285(15):11033-8.