CHIR 99021

• Supplier: Tocris Bioscience
• Catalog: 0846
• Prices: $209.00, $879.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 252917-06-9
• Chemical Name: 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
• Formula: C22H18Cl2N8
• Molecular Weight: 465.34
• Purity: >98 %
• Description: Potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3) (IC 50 values are 6.7 and 10 nM for GSK-3β and GSK-3α respectively). Exhibits >500-fold selectivity for GSK-3 over closely related kinases; also displays >800-fold selectivity against 45 additional enzymes and receptors. In combination with tranylcypromine (Cat. No. 3852), enables reprogramming of mouse embryonic fibroblasts, transduced by Oct4 and Klf4 only, into iPSCs. Enhances mouse and human ESC self-renewal when used in combination with PD 0325901 (Cat. No. 4192).

Product References

Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of - Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of

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Generation of human-induced pluripotent stem cells in the absence of exogenous - Generation of human-induced pluripotent stem cells in the absence of exogenous

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AKT kinase activity is required for lithium to modulate mood-related behaviors in - AKT kinase activity is required for lithium to modulate mood-related behaviors in

Pan JQ, Lewis MC, Ketterman JK, Clore EL, Riley M, Richards KR, Berry-Scott E, Liu X, Wagner FF, Holson EB, Neve RL, Biechele TL, Moon RT, Scolnick EM, Petryshen TL, Haggarty SJ. Neuropsychopharmacology. 2011 Jun;36(7):1397-411.

Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes - Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes

Ye S, Tan L, Yang R, Fang B, Qu S, Schulze EN, Song H, Ying Q, Li P. PLoS One. 2012;7(4):e35892.