CHIR 99021 trihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4423
• Prices: $235.00, $965.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1782235-14-6
• Chemical Name: 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitriletrihydrochloride
• Formula: C22H18Cl2N8.3HCl
• Molecular Weight: 574.72
• Purity: >98 %
• Description: Hydrochloride salt of CHIR 99021 (Cat. No. 4423), a highly selective GSK-3 inhibitor.

Product References

Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of - Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of

Ring DB, Johnson KW, Henriksen EJ, Nuss JM, Goff D, Kinnick TR, Ma ST, Reeder JW, Samuels I, Slabiak T, Wagman AS, Hammond ME, Harrison SD. Diabetes. 2003 Mar;52(3):588-95.

AKT kinase activity is required for lithium to modulate mood-related behaviors in - AKT kinase activity is required for lithium to modulate mood-related behaviors in

Pan JQ, Lewis MC, Ketterman JK, Clore EL, Riley M, Richards KR, Berry-Scott E, Liu X, Wagner FF, Holson EB, Neve RL, Biechele TL, Moon RT, Scolnick EM, Petryshen TL, Haggarty SJ. Neuropsychopharmacology. 2011 Jun;36(7):1397-411.

Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes - Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes

Ye S, Tan L, Yang R, Fang B, Qu S, Schulze EN, Song H, Ying Q, Li P. PLoS One. 2012;7(4):e35892.