8-Chloroadenosine

• Supplier: Tocris Bioscience
• Catalog: 3136
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Cas Number: 34408-14-5
• Chemical Name: 6-Amino-8-chloropurineriboside
• Formula: C10H12ClN5O4
• Molecular Weight: 301.69
• Purity: >98 %
• Description: Nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226 and U266 cancer cell lines; induces G 2 /M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells.

Product References

Exposure of human lung cancer cells to 8-chloro-adenosine induces G2/M arrest and - Exposure of human lung cancer cells to 8-chloro-adenosine induces G2/M arrest and

Zhang HY, Gu YY, Li ZG, Jia YH, Yuan L, Li SY, An GS, Ni JH, Jia HT. Neoplasia. 2004 Nov-Dec;6(6):802-12.

8-Chloro-adenosine inhibits growth at least partly by interfering with actin - 8-Chloro-adenosine inhibits growth at least partly by interfering with actin

Gu YY, Zhang HY, Zhang HJ, Li SY, Ni JH, Jia HT. Biochem Pharmacol. 2006 Aug 28;72(5):541-50. Epub 2006 Jul 17.

ATP analog enhances the actions of a heat shock protein 90 inhibitor in multiple - ATP analog enhances the actions of a heat shock protein 90 inhibitor in multiple

Cervantes-Gomez F, Nimmanapalli R, Gandhi V. J Pharmacol Exp Ther. 2011 Nov;339(2):545-54.