7-Chlorokynurenic acid

Name 7-Chlorokynurenic acid
Supplier Tocris Bioscience
Catalog 3697
Prices $79.00, $335.00
Sizes 10 mg, 50 mg
Function Type Antagonist
Cas Number 18000-24-3
Chemical Name 7-Chloro-4-hydroxyquinoline-2-carboxylicacid
Formula C10H6ClNO3
Molecular Weight 223.62
Purity >98 %
Description NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. Also available as part of the NMDA Receptor - Glycine Site Tocriset™ . 7-Chlorokynurenic acid sodium salt (Cat. No. 3697) also available.
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Product References

7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site - 7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site

Kemp JA, Foster AC, Leeson PD, Priestley T, Tridgett R, Iversen LL, Woodruff GN. Proc Natl Acad Sci U S A. 1988 Sep;85(17):6547-50.

Behavioral and neurochemical actions of the strychnine-insensitive glycine - Behavioral and neurochemical actions of the strychnine-insensitive glycine

Kretschmer BD, Bubser M, Schmidt WJ. Eur J Pharmacol. 1995 Jun 23;280(1):37-45.

Substituted quinolines as inhibitors of L-glutamate transport into synaptic - Substituted quinolines as inhibitors of L-glutamate transport into synaptic

Bartlett RD, Esslinger CS, Thompson CM, Bridges RJ. Neuropharmacology. 1998 Jul;37(7):839-46.