6-Chloromelatonin

• Supplier: Tocris Bioscience
• Catalog: 0237
• Prices: $89.00, $375.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 63762-74-3
• Chemical Name: N-[2-(6-Chloro-5-methoxyindol-3-yl)ethyl]acetamide
• Formula: C13H15ClN2O2
• Molecular Weight: 266.73
• Purity: >99 %
• Description: Potent melatonin agonist (pK i values are 9.10 and 9.77 for human recombinant MT 1 and MT 2 receptors respectively). Displays higher affinity for binding to hamster brain membrane and chicken retina than melatonin.

Product References

Luzindole (N-0774): a novel melatonin receptor antagonist. - Luzindole (N-0774): a novel melatonin receptor antagonist.

Dubocovich ML. J Pharmacol Exp Ther. 1988 Sep;246(3):902-10.

2-[125I]iodomelatonin binding sites in hamster brain membranes: pharmacological - 2-[125I]iodomelatonin binding sites in hamster brain membranes: pharmacological

Duncan MJ, Takahashi JS, Dubocovich ML. Endocrinology. 1988 May;122(5):1825-33.

Melatonin receptors: are there multiple subtypes? - Melatonin receptors: are there multiple subtypes?

Dubocovich ML. Trends Pharmacol Sci. 1995 Feb;16(2):50-6.

Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) - Pharmacological characterization of human recombinant melatonin mt(1) and MT(2)

Browning C, Beresford I, Fraser N, Giles H. Br J Pharmacol. 2000 Mar;129(5):877-86.